Effectiveness of 1-dimethylaminoethyl-4-benzylpiperidine (IN379) in prevention and regression of experimental atherosclerosis in the rabbit.

• In the search for effective treatment or prevention of atherosclerosis, a wide variety of substances, drugs, and procedures have been investigated in both animal and human studies. Examples of some of the types of compounds which have been employed include the lipotropic agents such as choline," and betaiue,'-'•"' heparin,'°~ sex hormones,' alpha tocopherol, detergents, plant sterols, cortisone, and ACTH. It also was found that certain procedures such as the production of experimental alloxan diabetes could influence the course of atherosclerosis in animals. Major emphasis has been placed on the influence of diet and the possible merits of low intake of fat and cholesterol. A recent article by Stamler reviews this field very well.